Tunicamycin-糖基化蛋白抑制剂-蛋白酶体抑制剂-ab120296

Key features and details

• Antibiotic. Protein glycosylation inhibitor.
• CAS Number: 11089-65-9
• Soluble in DMSO to 50 mM
• Form / State: Solid
• Source: Streptomyces sp.

• 产品名称

  Tunicamycin,蛋白glycosylation抑制剂

• 描述

  Antibiotic.蛋白glycosylation抑制剂.

• 生物学描述

  Nucleoside antibiotic that inhibits protein glycosylation. Inhibits GlcNAc phosphotransferase (GPT) and inhibits the transfer of N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Inhibits N-linked glycosylation and blocks the formation of  N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi and viruses.

• 常规说明

  This compound is a mixture of the homologs of tunicamycin: A, B, C and D which vary in the carbon chain length (n=8 to 11)

• CAS编号

  11089-65-9

• 化学结构

  

• 分子量

  844.95

• 分子式

  C₃₉H₆₄N ₄O₁₆ (for tunicamycin C, n = 10)

• PubChem识别号

  16220051

• 存放说明

  Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

• 溶解度概述

  Soluble in DMSO to 50 mM

• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Toxic, refer to SDS for further information.

• SMILES

  CC(C)CCCCCCCC/C=C/C(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1O[C@H]2[C@H]([C@@H]([C@H]([C@@H](O2)CO)O)O)NC(=O)C)C[C@H]([C@@H]3[C@H]([C@H]([C@@H](O3)N4C=CC(=O)NC4=O)O)O)O)O)O

• 来源

  Streptomyces sp.